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Our works in human and murine immunology have demonstrated that immune system is highly plastic, and can adapt to the environment prior to birth!

Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring

Lim AI, McFadden T, Link VM, Han SJ, Karlsson RM, Stacy A, Farley TK, Lima-Junior D, Harrison OJ, Desai JV, Lionakis MS, Shih HY, Cameron HA, Belkaid Y.

Science, 373, eabf3002 (2021) -- Read PDF

Pre-birth memory

Lim AI, Harrison OJ, Belkaid Y.

Nat Immunol. 2019 Mar; 20 (3), 254-256 -- Read PDF

ILC-poiesis: Ensuring tissue ILC differentiation at the right place and time

Lim AI, Di Santo JP.

Eur J Immunol. 2019 Jan; 49 (1): 11-18 -- Read PDF

Systemic human ILC precursors provide a substrate for tissue ILC differentiation

Lim AI, Li Y, Lopez-Lastra S, Stadhouders R, Paul F, Casrouge A, Serafini N, Puel A, Bustamante J, Surace L, Masse-Ranson G, David E, Strick-Marchand H, Le Bourhis L, Cocchi R, Topazio D, Graziano P, Muscarella LA, Rogge L, Norel X, Sallenave JM, Allez M, Graf T, Hendriks RW, Casanova JL, Amit I, Yssel H, Di Santo JP.

Cell. 2017 Mar 9; 168 (6): 1086-1100 -- Read PDF

Developmental options and functional plasticity of innate lymphoid cells

Lim AI, Verrier T, Vosshenrich C, Di Santo JP

Curr Opin Immunol. 2017 Mar 27; 44: 61-68 -- Read PDF

IL-12 drives functional plasticity of human group 2 innate lymphoid cells

Lim AI, Menegatti S, Bustamante J, Le Bourhis L, Allez M, Rogge L, Casanova JL, Yssel H, Di Santo JP.

J Exp Med. 2016 Apr 4; 213 (4): 569-83 -- Read PDF

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